翻訳と辞書 Words near each other ・ Phosphorus trisulfide ・ Phosphorus-31 nuclear magnetic resonance ・ Phosphorus-32 ・ Phosphoryl bromide ・ Phosphoryl chloride ・ Phosphoryl chloride (data page) ・ Phosphoryl fluoride ・ Phosphoryl group ・ Phosphoglycolate phosphatase ・ Phosphogypsum ・ Phosphohydroxypyruvic acid ・ Phosphoinositide 3-kinase ・ Phosphoinositide 3-kinase inhibitor ・ Phosphoinositide 5-phosphatase ・ Phosphoinositide phospholipase C ・ Phosphoinositide-dependent kinase-1 ・ Phosphoketolase ・ Phospholamban ・ Phosphole ・ Phospholipase ・ Phospholipase A ・ Phospholipase A1 ・ Phospholipase A2 ・ Phospholipase B ・ Phospholipase C ・ Phospholipase D ・ Phospholipase D1 ・ Phospholipid ・ Phospholipid acyltransferase ・ Phospholipid scramblase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Phosphoinositide-dependent kinase-1 ： ウィキペディア英語版 Phosphoinositide-dependent kinase-1 In the field of biochemistry, 3-phosphoinositide dependent protein kinase-1, also known as PDPK1 is a protein which in humans is encoded by the ''PDPK1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5170 )〕 It is implicated in the development and progression of melanomas. == Function == PDPK1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signalling pathways activated by several growth factors and hormones including insulin signaling. Mice lacking PDPK1 die during early embryonic development, indicating that this enzyme is critical for transmitting the growth-promoting signals necessary for normal mammalian development. Mice that are deficient in PDPK1 have a ≈40% decrease in body mass, mild glucose intolerance, and are resistant to cancer brought about by hyperactivation of the PI3K pathway (PTEN+/-). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Phosphoinositide-dependent kinase-1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.